Well, after about a week, these perfectly healthy rats started to sneeze and wheeze and even cough. Great, I though, more of the same. We took the rats to a vet, who gave us antibiotics to try for a week, and said if it had no effect, it had to be something in the environment. Nonsense, I though, I'm using corn cob litter, that can't bother them.
So, of course, a week later the medicine had not had any effect. But it was time to put in new, clean sisal rope. I had tied a lot of rope in the cage, and it was taking me a long time to get it all out, and to out the new rope in. As I was doing this, I started to itch, then sneeze, then cough, and finally a small dim light bulb in my head started to flicker on just a little . . .
I got rid of the rope, and all the rat's symptoms vanished in a few days. So the moral of the story is, don't use sisal rope in your rat cage.